Poly(2?oxazoline)? and Poly(2?oxazine)?Based Self?Assemblies, Polyplexes, and Drug Nanoformulations—An Update

For many decades, poly(2-oxazoline)s and poly(2-oxazine)s, two closely related families of polymers, have led the life a rather obscure research topic with only few groups world-wide working them. This has changed in last five to ten years, presumably triggered significantly by very promising clinical trials first poly(2-oxazoline)-based drug conjugate. The huge chemical structural toolbox poly(2-oxazine)s been extended but their potential still remains largely untapped. Here, specifically, developments macromolecular self-assemblies non-covalent delivery systems such as polyplexes nanoformulations based on are reviewed. highly dynamic field benefits particularly from extensive synthetic offer also may largest for further development. It is expected that dynamics will remain high next more about safety therapeutic learned.